Cellular aging is associated with a decline in a multitude of cellular functions and capabilities. Of particular note to the skin care industry is the decline in collagen, elastin and hyaluronic acid production by dermal fibroblasts. However, these three markers are just the tip of the iceberg in terms of the vast host of other aging related changes, giving materials tested in this area of research a broad range of potential targets against which to be screened for anti-aging effects.
- Fibroblasts, keratinocytes, and melanocytes available from various donor ages (from neonatal to elderly)
- Replicative senescence models
- Stress induced senescence models
Examples of Anti-Aging Studies
- Senescence associated B-Gal activity
- Maintained replicative capacity
- Sirtuin activity
- Maintained collagen, elastin and hyaluronic acid production
- p53/p21/p16 expression
- Maintained mitochondrial function
- Changes in DNA methylation
- Changes in global gene expression
- Pigmentation changes
Please note that only the typical targets are listed. If there are other aging related end points that your company has an interest in please let us know and we can accommodate you. Please contact us for specific pricing and study timing.